Switching yeast from meiosis to mitosis: double-strand break repair, recombination and synaptonemal complex

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SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination

Synapsis is the process by which paired chromosome homologues closely associate in meiosis before crossover. In the synaptonemal complex (SC), axial elements of each homologue connect through molecules of SYCP1 to the central element, which contains the proteins SYCE1 and -2. We have derived mice lacking SYCE2 protein, producing males and females in which meiotic chromosomes align and axes form...

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The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break r...

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ژورنال

عنوان ژورنال: Genes to Cells

سال: 1997

ISSN: 1356-9597,1365-2443

DOI: 10.1046/j.1365-2443.1997.1370335.x